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Rp-8-Br-cGMPS

CAT: 0931-T89142-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T89142-01Size:25 mg
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CAS Number
150418-07-8
Bioactivity
Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt acts as an effective activator of Ca2+-ATPase. Additionally, it serves as an agonist for rod CNG channels and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates the reduction of cytoplasmic Ca2+ by activating the Ca2+-ATPase enzyme, consequently removing Ca2+ from the cell.
Smiles
BrC=1N(C2=C(N1)C(=O)N=C(N)N2)[C@H]3[C@H](O)[C@]4([C@](O3)(COP(=O)(S)O4)[H])[H]
Molecular Formula
C10H11BrN5O6PS
Molecular Weight
440.17
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

8-Bromoguanosino-3',5'-cyclic monophosphorothioate
CAS Number150418-07-8
PubChem CID3035839
IUPAC Name(2R,5R)-2-(2-amino-8-bromopurin-9-yl)-5-(dihydroxyphosphinothioyloxymethyl)-2,5-dihydrofuran-3,4-diol
Molecular FormulaC10H11BrN5O6PS
Molecular Weight440.17
XLogP-0.2
Topological Polar Surface Area201
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count11
Rotatable Bond Count4
Heavy Atom Count24
Formal Charge0
Complexity580
SMILES
C1=C2C(=NC(=N1)N)N(C(=N2)Br)[C@H]3C(=C([C@H](O3)COP(=S)(O)O)O)O
InChI
InChI=1S/C10H11BrN5O6PS/c11-9-14-3-1-13-10(12)15-7(3)16(9)8-6(18)5(17)4(22-8)2-21-23(19,20)24/h1,4,8,17-18H,2H2,(H2,12,13,15)(H2,19,20,24)/t4-,8-/m1/s1
InChIKey
NKBRWLDMUXONRI-SPGJFGJESA-N
Chemical Structure
2D Structure
2D structure of 8-Bromoguanosino-3',5'-cyclic monophosphorothioate
CAS: 150418-07-8
CID: 3035839
Formula: C10H11BrN5O6PS
MW: 440.17
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight440.17
XLogP3-0.2
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count11
Rotatable Bond Count4
Exact Mass438.93510
Monoisotopic Mass438.93510
Topological Polar Surface Area201 Ų
Heavy Atom Count24
Formal Charge0
Complexity580
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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HY-135110ARp-8-Br-cGMPS
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A16030-5Rp-8-Br-PET-cGMPS 5mg
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