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COMT-IN-1

CAT: 0013-GTR19238227-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19238227-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
COMT-IN-1 (C12) is an orally bioavailable nitrophenol-based inhibitor with high selectivity for catechol-O-methyltransferase (IC50=0.37 μM) over MAO-A/B. It crosses the blood-brain barrier, chelates metal ions, elevates cerebral dopamine, and has shown efficacy in ameliorating MPTP-induced Parkinson's disease symptoms in murine models.
CAS Number
2987884-27-3
Field of Research
Signal Transduction
Smiles
FC1=CC=CC (COC (C=C2) =CC=C2CNC (/C (C#N) =C/C3=CC ([N+] ([O-]) =O) =C (C (O) =C3) O) =O) =C1
Molecular Formula
C24H18FN3O6
Molecular Weight
463.42
Storage Conditions
-20°C
Notes
For research use only.

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