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PPADS

CAT: 0931-T89112-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T89112-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
149017-66-3
Bioactivity
PPADS is a P2 receptor antagonist with IC50 values of 68 nM (P2X1) and 214 nM (P2X3) . This compound functions as an ATP (nucleotide) analog, competing for binding sites on the P2 receptors with ATP. Additionally, PPADS acts as a reversible competitive antagonist of the NAADP receptor. It is capable of reversing hyperalgesia, and it diminishes the enhanced NO/NOS signaling and IL-1? production in both peripheral and central steps of the nervous system.
Smiles
O=CC1=C(O)C(=NC(N=NC2=CC=C(C=C2S(=O)(=O)O)S(=O)(=O)O)=C1COP(=O)(O)O)C
Molecular Formula
C14H14N3O12PS2
Molecular Weight
511.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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