PPADS

CAT: 0804-HY-108960Size: 1 EachDry Ice: NoHazardous: No

CAT#:0804-HY-108960Size:1 Each

Selected

PRICE

AVAILABILITY: InStock

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

1 / 1

Description

PPADS is a P2 receptor antagonist, with IC50s of 68 nM (P2X1) and 214 nM (P2X3) . PPADS acts as an ATP (nucleotide) mimetic and competes with ATP for its binding site on P2 receptors. PPADS is also a reversible competitive antagonist of the NAADP receptor. PPADS reverses nociceptive hypersensitivity and reduces the increased NO/NOS system and IL-1β in both peripheral and central steps of nervous system[1][2][3].

CAS Number

[149017-66-3]

UNSPSC

12352005

Target

P2X Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ppads.html

Smiles

O=CC1=C(C(C)=NC(/N=N/C2=CC=C(S(=O)(O)=O)C=C2S(=O)(O)=O)=C1COP(O)(O)=O)O

Molecular Formula

C14H14N3O12PS2

Molecular Weight

511.38

References & Citations

[1]Billington RA, et al. PPADS is a reversible competitive antagonist of the NAADP receptor. Cell Calcium. 2007 Jun;41 (6) :505-11. |[2]Brown SG, et al. Actions of a Series of PPADS Analogs at P2X1 and P2X3 Receptors. Drug Dev Res. 2001 Aug;53 (4) :281-291. |[3]Martucci C, et al. The purinergic antagonist PPADS reduces pain related behaviours and interleukin-1 beta, interleukin-6, iNOS and nNOS overproduction in central and peripheral nervous system after peripheral neuropathy in mice. Pain. 2008 Jul;137 (1) :81-95.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

P2X1 Receptor; P2X2 Receptor

Citation 01

Related Products

Catalog	Name

Alternative Products

Catalog	Name
T89112-01	PPADS
M33471-01	PPADS tetrasodium
sc-204019	Iso-PPADS tetrasodium salt
256309-01	PPADS tetrasodium salt
sc-202770	PPADS tetrasodium salt, anhydrous

PPADS

Related Products

Alternative Products

Popular Products