IDH1/2-IN-1

CAT: 0931-T88989-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T88989-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Apoptosis, Isocitrate Dehydrogenase (IDH)

Related Pathways

Metabolism, Apoptosis

Bioactivity

IDH1/2-IN-1 (Compound 6b) is a dual inhibitor of IDH1 (R132H) /IDH2 (R140Q) with IC50 values of 0.22 μM and 1.6 μM, respectively. This compound effectively inhibits tumor growth by suppressing tumor cell proliferation and activating antioxidative enzymes to enhance host defense. Additionally, IDH1/2-IN-1 reduces inflammation and promotes apoptosis, demonstrating significant anti-tumor activity. It is also utilized in leukemia research.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-162772	IDH1/2-IN-1
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