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VIP236

CAT: 0931-T88950-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T88950-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2418533-90-9
Bioactivity
VIP236 is a small molecule drug conjugate (SMDCs) composed of an αvβ3 integrin binder linked to an optimized camptothecin topoisomerase I (TOP1) inhibitor payload. This compound exerts anticancer activity by targeting αvβ3 integrin and allows for the payloads release upon cleavage by neutrophil elastase in the tumor microenvironment.
Smiles
O=C1N2C(C3=NC4=CC=CC=C4C(CC)=C3C2)=CC5=C1COC([C@@]5(CC)OC([C@H](C(C)C)NC([C@H]6N(CCC6)C([C@H](CC([O-])=O)NC(CCOCCOCCOCCNC(NC7=CC=C(C=C7)NC(N[C@@H](C8=CC(NS(=O)(C9=CC(NC(NCCC)=O)=CC=C9)=O)=CC=C8)CC([O-])=O)=O)=O)=O)=O)=O)=O)=O.[Na+].[Na+]
Molecular Formula
C72H84N12Na2O20S
Molecular Weight
1515.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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