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ABT-751 hydrochloride

CAT: 0931-T88896-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T88896-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
141450-48-8
Bioactivity
ABT-751 (E7010) hydrochloride is a novel sulfonyl anti-mitotic compound and a tubulin binder with high oral bioavailability. This agent binds to the colchicine site on β-tubulin, inhibiting the polymerization of tubulin which results in cell cycle arrest at the G2/M phase and induces apoptosis, effectively preventing cell division. Additionally, ABT-751 (E7010) hydrochloride induces autophagy by inhibiting the AKT/MTOR signaling pathway. It exhibits significant inhibitory effects against various types of cancer cells, including lung, stomach, colon, and breast cancer.
Smiles
Cl.O=S(=O)(NC1=CC=CN=C1NC2=CC=C(O)C=C2)C3=CC=C(OC)C=C3
Molecular Formula
C18H18ClN3O4S
Molecular Weight
407.87
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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