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BA6b9

CAT: 0931-T88799-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T88799-03Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
609335-29-7
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
BA6b9 is an allosteric inhibitor targeting the SK4 channel via the CaM-PIP2 binding domain. It interacts with two critical residues, Arg191 and His192, located in the S4-S5 linker to inhibit the SK4 channel, with an IC50 of 8.6 μM (WT SK4) . BA6b9 significantly prolongs the effective refractory period (ERP) of the atria and atrioventricular node in isolated rat hearts, reducing the induction of atrial fibrillation (AF), highlighting its potential for arrhythmia research.
Smiles
O=C1OC=2C=CC=CC2N1CCCCCCC
Molecular Formula
C14H19NO2
Molecular Weight
233.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

3-Heptyl-1,3-benzoxazol-2-one
CAS Number609335-29-7
PubChem CID4490954
IUPAC Name3-heptyl-1,3-benzoxazol-2-one
Molecular FormulaC14H19NO2
Molecular Weight233.31
XLogP4.2
Topological Polar Surface Area29.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Heavy Atom Count17
Formal Charge0
Complexity255
SMILES
CCCCCCCN1C2=CC=CC=C2OC1=O
InChI
InChI=1S/C14H19NO2/c1-2-3-4-5-8-11-15-12-9-6-7-10-13(12)17-14(15)16/h6-7,9-10H,2-5,8,11H2,1H3
InChIKey
WANSKBZLGYAMMQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-Heptyl-1,3-benzoxazol-2-one
CAS: 609335-29-7
CID: 4490954
Formula: C14H19NO2
MW: 233.31
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight233.31
XLogP34.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Exact Mass233.141578849
Monoisotopic Mass233.141578849
Topological Polar Surface Area29.5 Ų
Heavy Atom Count17
Formal Charge0
Complexity255
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-163735BA6b9

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