Hit 14

• Target :

  Akt|||CXCR

• Related Pathways :

  Immunology/Inflammation|||PI3K/Akt/mTOR signaling|||Autophagy|||Cytoskeletal Signaling|||GPCR/G Protein

• Bioactivity :

  Hit 14, a CXCR4 (C-X-C chemokine receptor type 4) inhibitor, demonstrates an IC50 of 254 nM. It inhibits migration and invasion of MDA-MB-231 cells and suppresses Akt phosphorylation, exhibiting anti-inflammatory activity. Furthermore, Hit 14 improves ear swelling and damage in a mouse model.

• Smiles :

  O=S(=O)(NCC1OCCC1)C2=CC=C(OC3=CC=C(C=C3)S(=O)(=O)NCC4OCCC4)C=C2

• Molecular Formula :

  C22H28N2O7S2

• Molecular Weight :

  496.6

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  440338-68-1