Lipoamide

• Description :

  Lipoamide ((±) -α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway[1][2].

• Product Name Alternative :

  (±) -α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  NO Synthase

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/Lipoamide.html

• Purity :

  99.58

• Solubility :

  DMSO : ≥ 50 mg/mL

• Smiles :

  O=C(N)CCCCC1SSCC1

• Molecular Formula :

  C8H15NOS2

• Molecular Weight :

  205.34

• Precautions :

  H302

• References & Citations :

  [1]E S Arnér, et al. Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase. Biochem Biophys Res Commun. 1996 Aug 5;225 (1) :268-74.|[2]Hou Y, et al. Lipoamide Ameliorates Oxidative Stress via Induction of Nrf2/ARE Signaling Pathway in PC12 Cells. J Agric Food Chem. 2019 Jul 24;67 (29) :8227-8234.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Human Endogenous Metabolite

• CAS Number :

  [940-69-2]