HRS 4642

CAT: 0931-MF-0095516-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0095516-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2836263-09-1
Target
MEK|||Kras|||ERK|||Ras
Related Pathways
MAPK
Purity
0.9917
Bioactivity
HRS 4642 is a long-acting, selective KRAS G12D inhibitor with a Kd value of 0.083 nM. It inhibits phosphorylation of downstream MEK and ERK proteins, exhibiting antitumour activity. HRS 4642 reduces target lesions and, when used alone or in combination with Carfilzomib, remodels the tumour microenvironment towards an immunocompetent state.
Smiles
C(OC=1N=C2C3=C(N1)C(F)=C(N=C3OC[C@]4(N2C[C@@]5(N[C@]4(CC5)[H])[H])[H])C=6C7=C(C=CC(F)=C7CC)C=C(O)C6)[C@@]89N(C[C@H](F)C8)CCC9
Molecular Formula
C34H35F3N6O3
Molecular Weight
632.68
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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