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HRS 4642

CAT: 0013-GTR19236359-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19236359-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HRS 4642 is a potent and selective long-acting KRAS G12D inhibitor (Kd = 0.083 nM) that blocks MEK/ERK signaling, demonstrating antitumor efficacy in research models. It reduces tumor burden and, alone or combined with agents like Carfilzomib, promotes an immunocompetent tumor microenvironment in preclinical studies.
CAS Number
2836263-09-1
Product Name Alternative
HRS4642, HRS-4642
Field of Research
Signal Transduction
Purity
99.17% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:5 mg/mL (7.9 mM) ; DMSO:≥ 80 mg/mL
Smiles
C (OC=1N=C2C3=C (N1) C (F) =C (N=C3OC[C@]4 (N2C[C@@]5 (N[C@]4 (CC5) [H]) [H]) [H]) C=6C7=C (C=CC (F) =C7CC) C=C (O) C6) [C@@]89N (C[C@H] (F) C8) CCC9
Molecular Formula
C34H35F3N6O3
Molecular Weight
632.68
Storage Conditions
-20°C
Notes
For research use only.

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