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2-APQC

CAT: 0931-T88667-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T88667-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
500271-63-6
Target
Sirtuin
Related Pathways
DNA Damage/DNA Repair, Chromatin/Epigenetic
Purity
0.9988
Bioactivity
2-APQC is a selective, orally active Sirtuin-3 (SIRT3) agonist (Kd=2.756 μM) that modulates mitochondrial homeostasis. It attenuates ISO-induced myocardial hypertrophy and fibrosis in vivo and in vitro, making it suitable for heart failure research. 2-APQC inhibits mTOR-p70S6K, JNK, TGF-β/Smad3, and ROS-p38MAPK pathways while activating PYCR1 and AMPK-Parkin, thereby suppressing necrosis and mitigating mitochondrial oxidative damage.
Smiles
O=C(NCCCCC)C=1C=2N=C3C=CC=CC3=NC2N(C1N)CC4=CC=C(F)C=C4
Molecular Formula
C23H24FN5O
Molecular Weight
405.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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