Aftin-5

• Target:

  Beta Amyloid

• Related Pathways:

  Neuroscience

• Bioactivity:

  Aftin-5 is an inducer of amyloid beta protein 42 (A?42) . It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of A?42 and a downregulation of A?38 through a ?-secretase and ?-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-A?PP695 cells, with IC50 values of 180, 194, 178, and 150 ?M, respectively.

• Smiles:

  N(C)(C1=C2C(N(C(C)C)C=N2)=NC(N[C@H](CC)CO)=N1)C3=CC=CC=C3

• Molecular Formula:

  C19H26N6O

• Molecular Weight:

  354.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1461717-05-4