Aftin-5

CAT: 0931-T88257-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T88257-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1461717-05-4

Target

Beta Amyloid

Related Pathways

Neuroscience

Bioactivity

Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42) . It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.

Smiles

N(C)(C1=C2C(N(C(C)C)C=N2)=NC(N[C@H](CC)CO)=N1)C3=CC=CC=C3

Molecular Formula

C19H26N6O

Molecular Weight

354.45

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
2575-5	Aftin-5
BA8413-50	Aftin-4
A17139-10	Aftin-4 10mg

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