Aftin-4

CAT: 0931-T4364-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
CAT#:0931-T4364-01Size:1 mL - 10 mM (in DMSO)
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
866893-90-5
Target
Gamma-secretase|||Beta Amyloid
Related Pathways
Neuroscience|||Stem Cells|||Proteases/Proteasome
Purity
0.9903
Bioactivity
Aftin-4, an amyloid forty-two inducer, activates ?-secretase, promoting the generation of amyloid-?-1-42 (A?1-42) from amyloid-? protein precursor. Aftin-4 (Aftin4) increased A?-1-42, but not A?-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 (Aftin4) can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.
Smiles
CC[C@H](CO)Nc1nc(N(C)Cc2ccccc2)c2ncn(C(C)C)c2n1
Molecular Formula
C20H28N6O
Molecular Weight
368.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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Alternative Products

CatalogName
GL4073-1mgAftin-4
A17139-10Aftin-4 10mg
A17139-5Aftin-4 5mg
A17139-50Aftin-4 50mg
A17139-100Aftin-4 100mg
A17139-2Aftin-4 2mg
A17139-25Aftin-4 25mg
A17139-200Aftin-4 200mg
2575-5Aftin-5
A17139-10mM-DAftin-4 10mM * 1mL in DMSO

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