Aftin-4

• CAS Number :

  866893-90-5

• Target :

  Gamma-secretase|||Beta Amyloid

• Related Pathways :

  Neuroscience|||Stem Cells|||Proteases/Proteasome

• Purity :

  0.9903

• Bioactivity :

  Aftin-4, an amyloid forty-two inducer, activates ?-secretase, promoting the generation of amyloid-?-1-42 (A?1-42) from amyloid-? protein precursor. Aftin-4 (Aftin4) increased A?-1-42, but not A?-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 (Aftin4) can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.

• Smiles :

  CC[C@H](CO)Nc1nc(N(C)Cc2ccccc2)c2ncn(C(C)C)c2n1

• Molecular Formula :

  C20H28N6O

• Molecular Weight :

  368.48

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C