Aftin-4

• Target:

  Gamma-secretase|||Beta Amyloid

• Related Pathways:

  Neuroscience|||Stem Cells|||Proteases/Proteasome

• Purity:

  0.9903

• Bioactivity:

  Aftin-4, an amyloid forty-two inducer, activates ?-secretase, promoting the generation of amyloid-?-1-42 (A?1-42) from amyloid-? protein precursor. Aftin-4 (Aftin4) increased A?-1-42, but not A?-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 (Aftin4) can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.

• Smiles:

  CC[C@H] (CO) Nc1nc (N (C) Cc2ccccc2) c2ncn (C (C) C) c2n1

• Molecular Formula:

  C20H28N6O

• Molecular Weight:

  368.48

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  866893-90-5