HIF-2α-IN-11

CAT: 0931-T88241-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T88241-01Size:25 mg

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CAS Number

3034589-50-6

Target

HIF/HIF Prolyl-Hydroxylase

Related Pathways

Chromatin/Epigenetic, Metabolism

Bioactivity

HIF-2α-IN-11 (1) serves as a potent inhibitor of HIF-2α, exhibiting an IC 50 value of 59.2 nM.

Smiles

S(C(F)(F)F)(=O)(=O)C1=C2C(=C(C=C1)[C@@H]3C=4C(=CC(F)=CC4F)CCCC3)C[C@@H](F)[C@H]2O

Molecular Formula

C21H18F6O3S

Molecular Weight

464.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Hif-2|A-IN-11

CAS Number	3034589-50-6
PubChem CID	171714329
IUPAC Name	(1S,2R)-4-[(5R)-2,4-difluoro-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-yl]-2-fluoro-7-(trifluoromethylsulfonyl)-2,3-dihydro-1H-inden-1-ol
Molecular Formula	C21H18F6O3S
Molecular Weight	464.4
XLogP	5.5
Topological Polar Surface Area	62.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	2
Heavy Atom Count	31
Formal Charge	0
Complexity	753

SMILES

C1CCC2=C([C@H](C1)C3=C4C[C@H]([C@H](C4=C(C=C3)S(=O)(=O)C(F)(F)F)O)F)C(=CC(=C2)F)F

InChI

InChI=1S/C21H18F6O3S/c22-11-7-10-3-1-2-4-13(18(10)15(23)8-11)12-5-6-17(31(29,30)21(25,26)27)19-14(12)9-16(24)20(19)28/h5-8,13,16,20,28H,1-4,9H2/t13-,16-,20-/m1/s1

InChIKey

ATKXORIKCDITGR-OWDMVUQNSA-N

Chemical Structure

2D Structure

CAS: 3034589-50-6

CID: 171714329

Formula: C21H18F6O3S

MW: 464.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	464.4
XLogP3	5.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	2
Exact Mass	464.08808458
Monoisotopic Mass	464.08808458
Topological Polar Surface Area	62.8 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	753
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
HY-163598	HIF-2α-IN-11
PA1129-S	HIF-2α
XRC66682-01	HIF-2α-IN-2
TBI1508-5MG	HIF-2a-I2, HIF-2 antagonist
M32959-01	HIF-2α-IN-3
M28457-01	HIF-2α-IN-4
HY-19949-01	HIF-2α-IN-1
MBS5804053	HIF-1alpha-IN-2
BUP09166-01	HIF-2a-IN-2
BUP20680-01	HIF-1a-IN-2

HIF-2α-IN-11

Chemical Information

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