Pan-RAS-IN-2

CAT: 0931-T88116-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T88116-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

3034673-92-9

Target

Ras, Molecular Glues

Related Pathways

MAPK, PROTAC, GPCR/G Protein

Bioactivity

Pan-RAS-IN-2 (compound 6A) is a molecular glue that specifically targets RAS molecules, exhibiting significant inhibitory activity on the proliferation of RAS-mutated cell lines. It forms a ternary complex with cyclophilin A (CYPA) and RAS (ON) proteins, which blocks the downstream binding of RAF to RAS, thereby exerting antitumor effects.

Smiles

O=C1OCC(C)(C)CC=2C3=CC(=CC=C3N(C2C=4C=C(C=NC4C(OC)C)N5CCN(C)CC5)CC)C=6N=C(SC6)CC(NC(=O)C7C(C)C7C)C(=O)N8NC1C9CC8C9

Molecular Formula

C46H60N8O5S

Molecular Weight

837.08

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
GTR19234100-01	Pan-RAS-IN-2
381433	Ras, pan discontinued
C01512-01	Pan-RAS-IN-1
HY-168012	Pan-RAS-IN-6
sc-32	Pan Ras (F132)
GTR19262635-01	Pan-RAS-IN-5
HY-163594-01	Pan-RAS-IN-3
GTR19239632-01	Pan-RAS-IN-7
GTR19233983-01	Pan-RAS-IN-4

Pan-RAS-IN-2

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