EB-PSMA-617

CAT: 0931-T88040-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T88040-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2250333-97-0
Target
PSMA|||Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related|||Immunology/Inflammation
Bioactivity
EB-PSMA-617 is an advanced version of PSMA-617, designed to enhance pharmacokinetic properties through conjugation with Evans Blue (EB), thereby extending its circulation half-life for improved prostate tumor targeting and radiotherapy effectiveness. In preclinical studies with PC3-PIP-loaded mice, EB-PSMA-617 showed an extended blood half-life, greater accumulation in PSMA-positive tumors, and effective tumor elimination with reduced radioactivity.
Smiles
S(=O)(=O)(O)C=1C2=C(C(O)=C(N=NC3=C(C)C=C(C=C3)C4=CC(C)=C(NC([C@@H](NC(CN5CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC5)=O)CCCCNC(CCN6C(=O)C(SCC(NC[C@@H]7CC[C@@H](C(N[C@H](CC8=CC9=C(C=C8)C=CC=C9)C(NCCCC[C@H](NC(N[C@@H](CCC(O)=O)C(O)=O)=O)C(O)=O)=O)=O)CC7)=O)CC6=O)=O)=O)C=C4)C=C2)C(N)=C(S(=O)(=O)O)C1
Molecular Formula
C88H112N16O28S3
Molecular Weight
1938.12
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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