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DMBA-SIL-Mal-MMAE

CAT: 0931-T87862-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T87862-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2923885-49-6
Target
Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
DMBA-SIL-Mal-MMAE, a cytotoxin-linker conjugate designed for antibody-drug conjugates (ADC), exhibits significant antitumor activity. It incorporates the anti-mitotic agent monomethyl auristatin E (MMAE, a tubulin inhibitor) via the linker DMBA-SIL-Mal [1].
Smiles
[C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(OC(C(NCCOCCOCCOCCOCCN3C(=O)C=CC3=O)=O)C4=CC=C(NC(OCC5=CC(OC)=CC(OC)=C5)=O)C=C4)=O)C)C(C)C)=O)C(C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]
Molecular Formula
C72H106N8O20
Molecular Weight
1403.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

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GTR19234358-01DMBA-SIL-Mal-MMAE
HY-160703DMBA-SIL-PNP
HY-W011845-01DMBA
HY-170512-01Mal-GGFG-PAB-MMAE
HY-W011845R-01DMBA (Standard)
GTR19264438-01Mal-Val-Lys-PAB-MMAE
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BA2648-5Mal-PEG8-Val-Cit-PAB-MMAE
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