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Mal-PEG4-Val-Cit-PAB-MMAE

CAT: 0013-GTR19241253-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19241253-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This compound is the cleavable linker-payload component of antibody-drug conjugates (ADCs), comprising a Val-Cit-PAB protease-sensitive linker attached to the cytotoxic agent MMAE. It is widely used in ADC research for targeted cancer therapy, enabling the study of drug delivery and efficacy in both in vitro and in vivo models.
Field of Research
Signal Transduction
Purity
99.14% (May vary between batches)
Smiles
CC[C@@H] (C (N ([C@H] (C (NC ([C@H] (C (C) C) N (C (OCC1=CC=C (NC ([C@@H] (CCCNC (N) =O) NC ([C@H] (C (C) C) NC (CCOCCOCCOCCOCCN2C (C=CC2=O) =O) =O) =O) =O) C=C1) =O) C) =O) =O) C (C) C) C) [C@H] (OC) CC (N3CCC[C@H]3C ([C@H] (C (N[C@@H] ([C@H] (C4=CC=CC=C4) O) C) =O) C) OC) =O) C
Molecular Formula
C73H115N11O19
Molecular Weight
1450.76
Storage Conditions
-20°C
Notes
For research use only.

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HY-177680N- (Mal-PEG4) -N- (PEG4-Val-Cit-PAB-MMAE) -N- (PEG4-Val-Cit-PAB-Exatecan)
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