UCM-13369

• Target :

  Apoptosis

• Related Pathways :

  Apoptosis

• Bioactivity :

  UCM-13369 (Compound 4b) serves as an NPM1 inhibitor, effectively downregulating the pathway linked to mutant NPM1 C+ by specifically targeting the C-terminal DNA-binding domain of NPM1 C+. It induces apoptosis in AML cell lines and primary cells, making it a valuable tool for AML research [1].

• Smiles :

  C(CNCC1CC1)[C@@H]2C3=C(C[C@@H]([C@H]2N)C4=CC=C(OC)C=C4)NC=5C3=CC=CC5

• Molecular Formula :

  C25H31N3O

• Molecular Weight :

  389.53

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2921944-77-4