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TOP1288

CAT: 0931-T87546-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T87546-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1630202-02-6
Target
Src, Syk, p38 MAPK
Related Pathways
Tyrosine Kinase/Adaptors, MAPK, Angiogenesis
Bioactivity
TOP1288 is a narrow-spectrum kinase inhibitor targeting P38α, Src, and Syk kinases, with IC 50 values of 116nM, 24nM, and 659nM, respectively. It effectively inhibits inflammatory cytokine release from inflamed biopsies and myofibroblasts [1].
Smiles
O(C=1C2=C(C(NC(NC3=C(OC)C(NS(C)(=O)=O)=CC(C(C)(C)C)=C3)=O)=CC1)C=CC=C2)C4=NC(NC5=CC(C(NCCOCCOCCOC)=O)=CC(C#C)=C5)=NC=C4
Molecular Formula
C43H49N7O9S
Molecular Weight
839.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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