Products for Research Use Only
RegisterLogin

TOP1288

CAT: 0013-GTR19234549-02Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19234549-02Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
TOP1288 is a narrow-spectrum kinase inhibitor targeting P38α, Src, and Syk with IC50 values of 116 nM, 24 nM, and 659 nM, respectively. It effectively blocks inflammatory cytokine release in ex vivo biopsy and in vitro myofibroblast models, supporting its research use in studying inflammatory and fibrotic pathways.
CAS Number
1630202-02-6
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
O (C=1C2=C (C (NC (NC3=C (OC) C (NS (C) (=O) =O) =CC (C (C) (C) C) =C3) =O) =CC1) C=CC=C2) C4=NC (NC5=CC (C (NCCOCCOCCOC) =O) =CC (C#C) =C5) =NC=C4
Molecular Formula
C43H49N7O9S
Molecular Weight
839.96
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Top-1288

TOP-1288 is under investigation in clinical trial NCT02888379 (Phase 2a Study to Evaluate the Safety/Tolerability and Efficacy of TOP1288 200 mg Rectal Solution Once Daily for 4 Weeks in Ulcerative Colitis).

CAS Number1630202-02-6
PubChem CID81689783
IUPAC Name3-[[4-[4-[[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]carbamoylamino]naphthalen-1-yl]oxypyrimidin-2-yl]amino]-5-ethynyl-N-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]benzamide
Molecular FormulaC43H49N7O9S
Molecular Weight840.0
XLogP5.4
Topological Polar Surface Area209
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count13
Rotatable Bond Count21
Heavy Atom Count60
Formal Charge0
Complexity1500
SMILES
CC(C)(C)C1=CC(=C(C(=C1)NS(=O)(=O)C)OC)NC(=O)NC2=CC=C(C3=CC=CC=C32)OC4=NC(=NC=C4)NC5=CC(=CC(=C5)C(=O)NCCOCCOCCOC)C#C
InChI
InChI=1S/C43H49N7O9S/c1-8-28-23-29(40(51)44-17-18-57-21-22-58-20-19-55-5)25-31(24-28)46-41-45-16-15-38(49-41)59-37-14-13-34(32-11-9-10-12-33(32)37)47-42(52)48-35-26-30(43(2,3)4)27-36(39(35)56-6)50-60(7,53)54/h1,9-16,23-27,50H,17-22H2,2-7H3,(H,44,51)(H,45,46,49)(H2,47,48,52)
InChIKey
FWXVGKSWZJEPQI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Top-1288
CAS: 1630202-02-6
CID: 81689783
Formula: C43H49N7O9S
MW: 840.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight840.0
XLogP35.4
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count13
Rotatable Bond Count21
Exact Mass839.33124734
Monoisotopic Mass839.33124734
Topological Polar Surface Area209 Ų
Heavy Atom Count60
Formal Charge0
Complexity1500
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19196300-01TOP1210

Alternative Products

CatalogName
HY-160930TOP1288

Popular Products