SHP1-IN-1

CAT: 0931-T87388-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T87388-01Size:10 mg

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CAS Number

2956720-62-8

Target

Others, Phosphatase

Related Pathways

Others, Metabolism

Bioactivity

SHP1-IN-1 (compound 5p) serves as a fluorescent probe for the protein tyrosine phosphatase SHP1, which includes the Src homology 2 domain. This compound demonstrates selective inhibition of SHP1, affinity for Fe 3+ ions, and robust fluorescence characteristics. Additionally, SHP1-IN-1 exhibits an aggregation-caused quenching (ACQ) effect, has excellent resistance to interference, and maintains a low detection limit (5.55 μM) [1].

Smiles

N(C(C)(C)C)C=1N2C(=NC1C3=CC(C(O)=O)=C(O)C=C3)NC(=N2)C4=CC(OC)=CC=C4

Molecular Formula

C22H23N5O4

Molecular Weight

421.45

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Shp1-IN-1

CAS Number	2956720-62-8
PubChem CID	172638581
IUPAC Name	5-[6-(tert-butylamino)-2-(3-methoxyphenyl)-1H-imidazo[1,2-b][1,2,4]triazol-5-yl]-2-hydroxybenzoic acid
Molecular Formula	C22H23N5O4
Molecular Weight	421.4
XLogP	4.8
Topological Polar Surface Area	125
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Heavy Atom Count	31
Formal Charge	0
Complexity	644

SMILES

CC(C)(C)NC1=C(N=C2N1NC(=N2)C3=CC(=CC=C3)OC)C4=CC(=C(C=C4)O)C(=O)O

InChI

InChI=1S/C22H23N5O4/c1-22(2,3)25-19-17(12-8-9-16(28)15(11-12)20(29)30)23-21-24-18(26-27(19)21)13-6-5-7-14(10-13)31-4/h5-11,25,28H,1-4H3,(H,29,30)(H,23,24,26)

InChIKey

QYJFUFUWZGOYLF-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2956720-62-8

CID: 172638581

Formula: C22H23N5O4

MW: 421.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	421.4
XLogP3	4.8
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	421.17500423
Monoisotopic Mass	421.17500423
Topological Polar Surface Area	125 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	644
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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T12903-01	SHP2 IN-1
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T40250-01	SHP2 protein degrader-1
TMAC-03746-01	Anti-SHP-1 Antibody (7A74)
TMAS-00454-01	Anti-SHP substrate 1 Antibody (4D77)
TMPJ-00465-01	SHP-1/PTPN6 Protein, Human, Recombinant (His)
TMAC-03753-01	Anti-Phospho-SHP-1 (Tyr564) Polyclonal Antibody
TMAC-03752-01	Anti-Phospho-SHP-1 (Tyr536) Polyclonal Antibody

Alternative Products

Catalog	Name
GTR19291585-01	SHP1-IN-1
GTR19291586-01	SHP1 activator 1
E8M1505-4	SHP1
30R-1028	SHP1 protein
10R-8495	SHP1 antibody
506042-01	SHP1 discontinued
AF7787-BP	SHP1 Peptide

SHP1-IN-1

Chemical Information

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