Perforin-IN-2

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  Perforin-IN-2, a benzosulfonamide perforin inhibitor, mitigates transplant rejection in allogeneic bone marrow or stem cell transplantation. It binds to plasma proteins with a binding rate of 99.8%. In vivo, a concentration higher than 900 ?M is required for optimal perforin inhibition. Perforin-IN-2 effectively inhibits the lytic activity of recombinant perforin on Jurkat T leukemia cells, with an IC50 of 6.65 ?M, and also prevents the death of K562 leukemia target cells [1].

• Smiles:

  O=C1C=2C(=CC(C=3SC(=CC3)C=4C=C(NS(=O)(=O)C5=C(N(=O)=O)C=CC=C5)C=NC4)=CC2)CN1C

• Molecular Formula:

  C24H18N4O5S2

• Molecular Weight:

  506.55

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1567836-70-7