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Perforin-IN-2

CAT: 0931-T87130-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T87130-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1567836-70-7
Target
Others
Related Pathways
Others
Bioactivity
Perforin-IN-2, a benzosulfonamide perforin inhibitor, mitigates transplant rejection in allogeneic bone marrow or stem cell transplantation. It binds to plasma proteins with a binding rate of 99.8%. In vivo, a concentration higher than 900 μM is required for optimal perforin inhibition. Perforin-IN-2 effectively inhibits the lytic activity of recombinant perforin on Jurkat T leukemia cells, with an IC50 of 6.65 μM, and also prevents the death of K562 leukemia target cells [1].
Smiles
O=C1C=2C(=CC(C=3SC(=CC3)C=4C=C(NS(=O)(=O)C5=C(N(=O)=O)C=CC=C5)C=NC4)=CC2)CN1C
Molecular Formula
C24H18N4O5S2
Molecular Weight
506.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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