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NBI 35965 hydrochloride

CAT: 0931-T86978-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T86978-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1782228-59-4
Target
CRFR
Related Pathways
GPCR/G Protein
Bioactivity
NBI 35965 hydrochloride is a selective CRF1 (corticotropin-releasing factor receptor 1) antagonist that is both orally active and capable of penetrating the brain. It possesses a K i value of 4 nM and a pK i of 8.5, and does not affect CRF2. This compound effectively diminishes CRF or stress-triggered ACTH (adrenocorticotropic hormone) production in vivo, demonstrating pIC 50 values of 7.1 and 6.9. Additionally, NBI 35965 hydrochloride exhibits anxiolytic properties [1] [2].
Smiles
C(N1C2=C3C(C(=NN3C[C@@H]1CC)C4=C(Cl)C=C(Cl)C=C4)=NC(C)=C2)C5CC5.Cl
Molecular Formula
C21H23Cl3N4
Molecular Weight
437.79
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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