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Mca-SEVNLDAEFK (Dnp)

CAT: 0931-T86868-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T86868-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1802078-31-4
Target
Others, Beta-Secretase
Related Pathways
Neuroscience, Others
Bioactivity
Mca-SEVNLDAEFK (Dnp) is a peptide FRET substrate for Beta-secretase 1 (BACE-1), featuring the 'Swedish' Lys-Met/Asn-Leu mutation at the β-secretase cleavage site of the amyloid precursor protein (APP) . Cleavage at the -Leu-Asp- site of Mca-SEVNLDAEFK (Dnp) releases the highly fluorescent 7-methoxycoumarin (Mca) fragment, which is freed from the quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher, leading to a significantly increased fluorescence intensity that is easily detectable.
Smiles
C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCCNC2=C(N(=O)=O)C=C(N(=O)=O)C=C2)C(O)=O)=O)=O)CCC(O)=O)=O)C)=O)CC(O)=O)=O)CC(C)C)=O)CC(N)=O)=O)C(C)C)=O)CCC(O)=O)=O)CO)=O)C=3C=4C(=CC(OC)=CC4)OC(=O)C3
Molecular Formula
C68H88N14O27
Molecular Weight
1533.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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