HDAC6-IN-34

CAT: 0931-MF-0147625-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0147625-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1432508-73-0
Target
HDAC
Related Pathways
DNA Damage/DNA Repair|||Chromatin/Epigenetic
Bioactivity
HDAC6-IN-34 (compound 21), an orally active, selective HDAC6 inhibitor, exhibits an IC50 of 18 nM. It enhances tubulin acetylation levels without impacting histone acetylation in cutaneous T-cell lymphoma cells and suppresses TNF-? secretion in LPS-stimulated macrophage cells. Furthermore, HDAC6-IN-34 demonstrates outstanding anti-arthritic efficacy in rats [1].
Smiles
C(N1C2=C(C(C(F)(F)F)=N1)C(=O)CC(C)(C)C2)C3=CC=C(C(NO)=O)C=C3
Molecular Formula
C18H18F3N3O3
Molecular Weight
381.35
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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