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Gambogic amide

CAT: 0931-T86491-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T86491-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
286935-60-2
Target
Akt, ERK, Trk receptor
Related Pathways
PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, MAPK, Tyrosine Kinase/Adaptors
Bioactivity
Gambogic amide acts as a potent and selective agonist for TrkA, promoting tyrosine phosphorylation and activating downstream signaling pathways such as Akt and MAPK. It specifically binds to the cytoplasmic juxtamembrane domain of the TrkA receptor, stimulating dimerization and activation. The compound demonstrates neuroprotective properties by preventing neuronal cell death caused by glutamate. Additionally, gambogic amide shows enhanced efficacy in a transient middle cerebral artery occlusion model of stroke and may be useful for investigating neurodegenerative diseases and stroke [1].
Smiles
C(/C=C(\C(N)=O)/C)[C@@]12[C@]34C(C(=O)C=5C(O3)=C(CC=C(C)C)C6=C(C5O)C=C[C@](CCC=C(C)C)(C)O6)=CC(C1=O)(C[C@]4(C(C)(C)O2)[H])[H]
Molecular Formula
C38H45NO7
Molecular Weight
627.77
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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