Gambogic Acid

• Target :

  Bcl-2 Family|||Autophagy

• Related Pathways :

  Autophagy|||Apoptosis

• Purity :

  0.9867

• Bioactivity :

  Gambogic Acid (Guttic Acid) (EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 uM, respectively.

• Smiles :

  CC(C)=CCCC1(C)OC2=C(CC=C(C)C)C3=C(C(O)=C2C=C1)C(=O)C1=CC2CC4C(C)(C)OC(C\C=C(/C)C(O)=O)(C2=O)C14O3

• Molecular Formula :

  C38H44O8

• Molecular Weight :

  628.75

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2752-65-0