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DCLK1-IN-5

CAT: 0931-T86170-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T86170-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3028774-14-0
Target
Serine Protease
Related Pathways
Proteases/Proteasome
Bioactivity
DCLK1-IN-5 (Compound a24), with an IC 50 of 179.7 nM, acts as a DCLK1 inhibitor. It mitigates lipopolysaccharide-induced inflammation by blocking DCLK1-mediated IKKβ phosphorylation. Additionally, DCLK1-IN-5 offers protection to mice from lung injuries and sepsis caused by inflammation [1].
Smiles
S(C(C)C)(=O)(=O)C1=C(NC2=NC(NC3=C(OC)C=C(NC(=S)N4CCN(C)CC4)C=C3)=NC=C2Cl)C=CC=C1
Molecular Formula
C26H32ClN7O3S2
Molecular Weight
590.16
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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