ATF4-IN-1

CAT: 0931-T85739-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T85739-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2991057-76-0

Target

Others, PERK

Related Pathways

Others, Apoptosis

Bioactivity

ATF4-IN-1 (Compound 21) serves as an inhibitor of ATF4, demonstrating effective suppression of ATF4 expression in Thapsigargin-stimulated HEK-293T cells with an IC50 of 32.43 nM. Compared to ISRIB, ATF4-IN-1 shows enhanced activity and exhibits minimal cytotoxicity, with an IC50 of 96 μM in HEK-293T cells. This compound is utilized in the investigation of neurodegenerative diseases [1].

Smiles

ClC=1C=C2C=C(OC2=CC1)C=3OC(=NN3)[C@@H]4CC[C@@H](NC(COC5=CC=C(Cl)C=C5)=O)CC4

Molecular Formula

C24H21Cl2N3O4

Molecular Weight

486.35

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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GTR19235583-01	ATF4-IN-1
BZ0162-2	PcDNA3.1-ATF4
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YP-W31076-01	Rat ATF4 (ATF4) ELISA Kit
70R-51458	ATF4 antibody
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DF6008-BP	ATF4 Peptide

ATF4-IN-1

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