Ack1 inhibitor 1

CAT: 0931-T85583-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T85583-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2924415-92-7

Target

Akt, ACK1

Related Pathways

PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling

Bioactivity

Ack1 inhibitor 1 is a potent and selective orally active inhibitor of ACK1 kinase, with an IC50 value of 2.1 nM. It effectively inhibits the phosphorylation of ACK1 and the activation of downstream AKT, demonstrating anti-tumor activity [1].

Smiles

C(N1C=2C(C=C(C1=O)C3=CC(NC(=O)C4=CC(C(F)(F)F)=CC=C4)=CC=C3)=CN=C(NC5=C(OCC)C=C(C=C5)N6CCN(C)CC6)N2)[C@H]7CCCO7

Molecular Formula

C39H40F3N7O4

Molecular Weight

727.77

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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