4-Br-Bnlm

• Target:

  Others|||HSP

• Related Pathways:

  Others|||Cytoskeletal Signaling|||Metabolism

• Bioactivity:

  4-Br-Bnlm, with an EC 50 of 0.96 µM, acts as a selective inhibitor of glucose-regulated protein 94 (Grp94) . It effectively reduces both mutant and wild-type misfolded myocilin proteins in cells, thereby enhancing the clearance of toxic forms of myocilin and diminishing myocilin toxicity [1] [2].

• Smiles:

  C(OC)(=O)C1=C(CCC=2N(CC3=CC=C(Br)C=C3)C=CN2)C(Cl)=C(O)C=C1O

• Molecular Formula:

  C20H18BrClN2O4

• Molecular Weight:

  465.72

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1654775-71-9