6-hydroxy Bexarotene

• Target :

  Others|||Endogenous Metabolite

• Related Pathways :

  Metabolism|||Others

• Bioactivity :

  6-Hydroxy Bexarotene, an oxidative metabolite of bexarotene, serves as a high-affinity ligand for retinoid X receptors (RXRs), specifically binding to RXR?, RXR?, and RXR?, as well as to the retinoic acid receptor ? (RAR?) with dissociation constants (Kds) of 3.46, 4.21, 4.83, and 8.17 ?M, respectively. It demonstrates selective activation of RXR?, RXR?, and RXR? over RAR?, RAR?, and RAR? in vitro, with half-maximal effective concentrations (EC50s) of 398, 356, 420, 4,414, 2,121, and 2,043 nM, respectively.

• Smiles :

  Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CC(O)C2(C)C

• Molecular Formula :

  C24H28O3

• Molecular Weight :

  364.485

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  368451-07-4