18-hydroxy-11-deoxy Corticosterone

CAT: 0931-T85153-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T85153-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

379-68-0

Target

Others, Glucocorticoid Receptor, Melanocortin Receptor, RAAS, Drug Metabolite

Related Pathways

Endocrinology/Hormones, GPCR/G Protein, Metabolism, Neuroscience, Others

Bioactivity

18-Hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid produced by the zona fasciculata of the adrenal gland, with its biosynthesis regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. This regulation heightens 18-OH-DOC production in isolated human adrenal glomerulosa cells and allows for its formation from 11-deoxy corticosterone (DOC) in human SK-MEL188 melanoma cells. As an intermediate in progesterone metabolism, 18-OH-DOC can be converted to aldosterone in rat adrenal glands' capsular portion. Its continuous infusion (200 μg/rat per day) has been shown to raise systolic blood pressure in uninephrectomized saline-drinking rats, and elevated plasma levels of 18-OH-DOC have been observed in the adb/db mouse model of type 2 diabetes.

Smiles

C(O)[C@@]12[C@]([C@]3([C@](CC1)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])(CC[C@@H]2C(CO)=O)[H]

Molecular Formula

C21H30O4

Molecular Weight

346.46

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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GTR19232291	18-hydroxy-11-deoxy Corticosterone
TRC-D232590-10MG	11-Deoxy Corticosterone
TRC-H824960-50MG	18-Hydroxy Corticosterone
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MBS6044804-01	11-Deoxy Corticosterone-d8
sc-470983	11-Deoxy Corticosterone-d7
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18-hydroxy-11-deoxy Corticosterone

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