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Myrothecine A

CAT: 0931-T85069-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T85069-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
910292-40-9
Target
JNK, Others, PARP, Caspase, Bcl-2 Family, Apoptosis, Cytochromes P450
Related Pathways
Chromatin/Epigenetic, Apoptosis, Proteases/Proteasome, Metabolism, MAPK, Others, DNA Damage/DNA Repair
Bioactivity
Myrothecine A, a trichothecene mycotoxin discovered in M. roridum, exhibits anticancer properties. It effectively inhibits the proliferation of various cancer cell lines, specifically A549, MCF-7, HepG2, and SMMC-7721, with IC50 values of 95, 70, 60, and 25 μM, respectively. At a concentration of 50 μM, Myrothecine A induces G1 cell cycle arrest in HepG2 cells and promotes apoptosis in SMMC-7721 cells by elevating levels of Bax and cleaved caspase-3, -5, and -8.
Molecular Formula
C29H38O10
Molecular Weight
546.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-N8508Myrothecine A

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