Products for Research Use Only
RegisterLogin

Myrothecine A

CAT: 0804-HY-N8508Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-N8508Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Myrothecine A is a trichothecene mycotoxin found in M. roridum. Myrothecine A induces apoptosis, promotes the cytochrome c release, PARP-cleavage and phosphorylation of JNK, increases Bax and cleaved caspase-3, -5, and -8 levels. Myrothecine A has anticancer activities and promotes the maturation of DC cells in the microenvironment. Myrothecine A inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells with IC50s of 95, 70, 60, and 25 µM, respectively[1][2][3].
CAS Number
910292-40-9
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; Cytochrome P450; JNK; PARP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CC1([C@@](OC(/C=C\CC[C@@]23C(C)=O)=O)([H])C[C@@]4([H])O5)[C@](CC[C@](O)6C)(COC(/C=C(CCO3)\[C@H]2O)=O)[C@H]5[C@]6([H])CC14O
Molecular Formula
C29H38O10
Molecular Weight
546.61
References & Citations
[1]1. Fu Y, et al. Myrothecine A modulates the proliferation of HCC cells and the maturation of dendritic cells through downregulating miR-221. Int Immunopharmacol. 2019 Oct;75:105783. |[2]2. Lin T, et al. Structure elucidation and biological activity of two new trichothecenes from an endophyte, Myrothecium roridum. J Agric Food Chem. 2014 Jun 25;62 (25) :5993-6000. |[3]3. Song H, et al. Mytoxin B and Myrothecine A Induce Apoptosis in Human Hepatocarcinoma Cell Line SMMC-7721 via PI3K/Akt Signaling Pathway. Molecules. 2019 Jun 20;24 (12) :2291.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Bax; Caspase 3; Caspase 5; Caspase 8

Alternative Products

CatalogName
GTR19232380Myrothecine A

Popular Products