PON-PC

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  PON-PC, an oxidized phospholipid with a 9-carbon fatty acyl chain ending in an aldehyde at the sn-2 position, arises from the oxidation of palmitoyl oleoyl phosphatidylcholine (POPC) or through interaction with ozone in pulmonary surfactant. It is found in oxidized LDL. At a 40 µM concentration, PON-PC diminishes the production of TNF-?, nitric oxide (NO), and NADP+ in primary mouse alveolar macrophages and lowers the bactericidal capability of RAW 264.7 cells. Additionally, levels of PON-PC increase in the bronchoalveolar lavage fluid (BALF) of mice exposed to cigarette smoke or in older mice.

• Smiles:

  [C@@H](COP(OCC[N+](C)(C)C)(=O)[O-])(OC(CCCCCCCC=O)=O)COC(CCCCCCCCCCCCCCC)=O

• Molecular Formula:

  C33H64NO9P

• Molecular Weight:

  649.4

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  135726-46-4