PON-PC

CAT: 0931-MF-0120186-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0120186-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
135726-46-4
Target
Others
Related Pathways
Others
Bioactivity
PON-PC, an oxidized phospholipid with a 9-carbon fatty acyl chain ending in an aldehyde at the sn-2 position, arises from the oxidation of palmitoyl oleoyl phosphatidylcholine (POPC) or through interaction with ozone in pulmonary surfactant. It is found in oxidized LDL. At a 40 µM concentration, PON-PC diminishes the production of TNF-?, nitric oxide (NO), and NADP+ in primary mouse alveolar macrophages and lowers the bactericidal capability of RAW 264.7 cells. Additionally, levels of PON-PC increase in the bronchoalveolar lavage fluid (BALF) of mice exposed to cigarette smoke or in older mice.
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[C@@H](COP(OCC[N+](C)(C)C)(=O)[O-])(OC(CCCCCCCC=O)=O)COC(CCCCCCCCCCCCCCC)=O
Molecular Formula
C33H64NO9P
Molecular Weight
649.4
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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