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α-Cortolone

CAT: 0931-T84945-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T84945-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
516-42-7
Target
Others, Glucocorticoid Receptor
Related Pathways
Endocrinology/Hormones, Others
Bioactivity
α-Cortolone, a metabolite of the glucocorticoid cortisol (hydrocortisone), is produced through the action of 20α-hydroxysteroid dehydrogenase (20α-HSD) via a tetrahydrocortisone (THE) intermediate. Studies indicate that urinary levels of α-cortolone are reduced in patients experiencing severe anorexia nervosa and postmenopausal women diagnosed with endometrial adenocarcinoma, in comparison to postmenopausal women without the condition.
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C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(C(=O)C1)[H])[H])(CC[C@@]2([C@H](CO)O)O)[H]
Molecular Formula
C21H34O5
Molecular Weight
366.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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