DBCO-PEG2-NHS ester

• Target:

  ADC Linker

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Bioactivity:

  DBCO-PEG2-NHS ester is a click chemistry reagent featuring an azide group and an NHS ester, designed for copper-free Click Chemistry. It specifically and efficiently reacts with primary amines (e.g., lysine residue side chains or aminosilane-coated surfaces) under neutral or slightly basic conditions to form stable covalent bonds. The inclusion of a hydrophilic PEG spacer enhances water solubility and provides a flexible linkage, reducing steric hindrance during ligation. This compound, intended for research use only [1], is ideal for applications requiring precise and efficient bioconjugation.

• Smiles:

  C(CCC(NCCOCCOCCC(ON1C(=O)CCC1=O)=O)=O)(=O)N2C=3C(C#CC=4C(C2)=CC=CC4)=CC=CC3

• Molecular Formula:

  C30H31N3O8

• Molecular Weight:

  561.58

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2585653-12-7