DBCO-PEG4-GGFG-Dxd

CAT: 0931-MF-0120022-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0120022-01Size:10 mg
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CAS Number
2694856-51-2
Target
Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
DBCO-PEG4-GGFG-Dxd is a conjugate used in antibody-drug conjugates (ADCs) exhibiting potent antitumor activity. It incorporates Dxd, a DNA topoisomerase I inhibitor, connected through the cleavable linker DBCO-PEG4-GGFG [1]. This compound functions as a click chemistry reagent, featuring a DBCO group capable of strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.
Smiles
N(C(COCNC(CNC([C@H](CC1=CC=CC=C1)NC(CNC(CNC(CCOCCOCCOCCOCCNC(CCC(=O)N2C=3C(C#CC=4C(C2)=CC=CC4)=CC=CC3)=O)=O)=O)=O)=O)=O)=O)[C@@H]5C6=C7C(C=8N(C7)C(=O)C9=C(C8)[C@](CC)(O)C(=O)OC9)=NC=%10C6=C(CC5)C(C)=C(F)C%10
Molecular Formula
C72H79FN10O17
Molecular Weight
1375.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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