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(E) -2-Hexadecenal

CAT: 0931-T84418-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T84418-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
22644-96-8
Target
Microtubule Associated, Others, JNK, MLK, Apoptosis
Related Pathways
MAPK, Apoptosis, Cytoskeletal Signaling, Others
Bioactivity
Sphingosine-1-phosphate (S1P), a bioactive lipid crucial in numerous signaling pathways, undergoes irreversible degradation by membrane-bound S1P lyase, producing (E) -2-Hexadecenal, a derivative of sphingolipid breakdown. This compound can be oxidized to (2E) -hexadecenoic acid by long-chain fatty aldehyde dehydrogenase before being activated through linkage to coenzyme A. Notably, (E) -2-Hexadecenal induces cytoskeletal reorganization, leading to cell rounding, detachment, activation of JNK pathway targets, and ultimate apoptosis in a variety of cell types. Furthermore, it readily forms aldehyde-derived DNA adducts through reactions with deoxyguanosine and DNA.
Smiles
CCCCCCCCCCCCC\C=C\C=O
Molecular Formula
C16H30O
Molecular Weight
238.415
Shipping Conditions
Ice Packs
Storage Temperature
-20°C