(E) -2-Hexadecenal

• Target :

  Microtubule Associated|||Others|||JNK|||MLK|||Apoptosis

• Related Pathways :

  MAPK|||Apoptosis|||Cytoskeletal Signaling|||Others

• Bioactivity :

  Sphingosine-1-phosphate (S1P), a bioactive lipid crucial in numerous signaling pathways, undergoes irreversible degradation by membrane-bound S1P lyase, producing (E) -2-Hexadecenal, a derivative of sphingolipid breakdown. This compound can be oxidized to (2E) -hexadecenoic acid by long-chain fatty aldehyde dehydrogenase before being activated through linkage to coenzyme A. Notably, (E) -2-Hexadecenal induces cytoskeletal reorganization, leading to cell rounding, detachment, activation of JNK pathway targets, and ultimate apoptosis in a variety of cell types. Furthermore, it readily forms aldehyde-derived DNA adducts through reactions with deoxyguanosine and DNA.

• Smiles :

  CCCCCCCCCCCCC\C=C\C=O

• Molecular Formula :

  C16H30O

• Molecular Weight :

  238.415

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  22644-96-8