HA-14-1

CAT: 0931-T84388-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T84388-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

927635-64-1

Target

Others, Bcl-2 Family

Related Pathways

Apoptosis, Others

Bioactivity

HA-14-1, a small molecule, binds the surface pocket of Bcl-2 proteins (IC50= ~ 9 μM), including Bcl-xl and Bcl-W, and disrupts their interaction with the Bak peptide. This action induces apoptosis by activating Apaf-1 and caspase-9 and -3. Additionally, HA-14-1 effectively induces apoptosis in human acute myeloid leukemia (HL-60) cells, with a 50 μM concentration resulting in a 90% loss of cell viability.

Smiles

C(C(OCC)=O)(C#N)C1C=2C(OC(N)=C1C(OCC)=O)=CC=C(Br)C2

Molecular Formula

C17H17BrN2O5

Molecular Weight

409.2

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
GTR19232949-01	HA-14-1
410464-01	1,1,14,14-Tetrachlorotetradecane
BA8154-10	Enpp-1-IN-14
4095839.0001	ACTH (1-14)
GTR19113211-01	β-Amyloid (1-14)
D10650	1,14-Dibromotetradecane
sc-253960	1,14-Tetradecanediol
GTR19238803-01	14α-Demethylase-IN-1
M29937-01	ACTH 1-14
HAA73502-01	1,14-Tetradecanediamine

HA-14-1

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