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Cytogenin

CAT: 0931-T83916-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T83916-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
132971-59-6
Target
Others, Interleukin, NO Synthase
Related Pathways
Immunology/Inflammation, Others
Bioactivity
Cytogenin, a coumarin derivative isolated from S. eurocidicum, exhibits multiple biological effects. It notably diminishes tumor mass in an Ehrlich murine spontaneous adenocarcinoma model with a daily administration of 25 mg/kg. Furthermore, cytogenin (30 and 100 mg/kg per day) counteracts the body weight reduction and the rise in plasma glucose levels induced by streptozotocin, along with reducing pancreatic macrophage infiltration in a diabetes mouse model. Additionally, at a dose of 100 mg/kg per day, it suppresses nitric oxide production triggered by zymosan and LPS, as well as the LPS-induced increase in Il-6 levels in isolated mouse macrophages.
Smiles
O=C1OC(CO)=CC2=C1C(O)=CC(OC)=C2
Molecular Formula
C11H10O5
Molecular Weight
222.19
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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