N-didesmethyl Loperamide

• Target :

  Others|||Drug Metabolite

• Related Pathways :

  Others|||Metabolism

• Bioactivity :

  N-didesmethyl Loperamide, an active metabolite of the peripheral ?1-opioid receptor agonist loperamide, impedes electrically induced contractions in isolated guinea pig myenteric plexus (IC50 = 370 nM) and enhances the sensitivity of a chloroquine-resistant P. falciparum strain to chloroquine (EC50 = 482 nM) . Notably, it achieves this without causing toxicity in A-10 vascular smooth muscle cells (IC50 = >10,000 nM) .

• Smiles :

  NC(C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN3CCC(C4=CC=C(Cl)C=C4)(O)CC3)=O

• Molecular Formula :

  C27H29ClN2O2

• Molecular Weight :

  448.98

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  66164-06-5