N-didesmethyl Loperamide

CAT: 0931-T83899Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T83899Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

66164-06-5

Target

Others, Drug Metabolite

Related Pathways

Others, Metabolism

Bioactivity

N-didesmethyl Loperamide, an active metabolite of the peripheral μ1-opioid receptor agonist loperamide, impedes electrically induced contractions in isolated guinea pig myenteric plexus (IC50 = 370 nM) and enhances the sensitivity of a chloroquine-resistant P. falciparum strain to chloroquine (EC50 = 482 nM) . Notably, it achieves this without causing toxicity in A-10 vascular smooth muscle cells (IC50 = >10,000 nM) .

Smiles

NC(C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN3CCC(C4=CC=C(Cl)C=C4)(O)CC3)=O

Molecular Formula

C27H29ClN2O2

Molecular Weight

448.98

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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N-didesmethyl Loperamide

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