N-didesmethyl Loperamide

• Target:

  Others|||Drug Metabolite

• Related Pathways:

  Others|||Metabolism

• Bioactivity:

  N-didesmethyl Loperamide, an active metabolite of the peripheral ?1-opioid receptor agonist loperamide, impedes electrically induced contractions in isolated guinea pig myenteric plexus (IC50 = 370 nM) and enhances the sensitivity of a chloroquine-resistant P. falciparum strain to chloroquine (EC50 = 482 nM) . Notably, it achieves this without causing toxicity in A-10 vascular smooth muscle cells (IC50 = >10,000 nM) .

• Smiles:

  NC (C (C1=CC=CC=C1) (C2=CC=CC=C2) CCN3CCC (C4=CC=C (Cl) C=C4) (O) CC3) =O

• Molecular Formula:

  C27H29ClN2O2

• Molecular Weight:

  448.98

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  66164-06-5