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Os30

CAT: 0931-T81596-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T81596-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, EGFR
Related Pathways
JAK/STAT signaling, Apoptosis, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
Os30 is a potent fourth-generation EGFR inhibitor, specifically targeting the EGFRC797S-TK mutation with IC50 values of 18 nM for EGFRDel19/T790M/C797S TK and 113 nM for EGFRL858R/T790M/C797S TK. It effectively suppresses EGFR phosphorylation, induces G1 phase arrest, and triggers apoptosis in KC-0116 (BaF3-EGFRDel19/T790M/C797S) cells. Moreover, Os30 demonstrates strong antitumor activity in non-small cell lung cancer (NSCLC) harboring the EGFmRC797S mutation [1].
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
MBS5823248Os30
ISS-E300Attachment with 4 clamping rolls for IS-OS30
ISS-E320Dish Attachment with non-slip mat for IS-OS30
ISS-E305Base Plate to be used with Fix ing clips for IS-OS30

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