QL-1200186

• Target:

  JAK

• Related Pathways:

  JAK/STAT signaling|||Stem Cells|||Angiogenesis|||Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors

• Bioactivity:

  QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-? (IFN?) production following interleukin-12 (IL-12) stimulation and markedly improves skin lesions in a psoriatic mouse model [1].

• Smiles:

  O=C (NC) C1=CN=C2C=C1NC3=CC (=CC (C4=NN (C=C4) C) =C3OC) CCOCC5=NC (=CC=C5) N2

• Molecular Formula:

  C26H27N7O3

• Molecular Weight:

  485.54

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2848664-42-4