SFNGGP-NH2

• Target:

  Protease-activated Receptor

• Related Pathways:

  GPCR/G Protein

• Bioactivity:

  SFNGGP-NH2 is a biologically active peptide that interacts with Protease-Activated Receptor 3 (PAR-3), a high-affinity thrombin receptor. Human cutaneous mast cells express PAR-3 mRNA, implicating a role in itch mechanotransduction, with both histamine-dependent and independent pathways reported. While PAR-3 alone does not induce itch, it may potentiate itch when co-expressed with PAR-4, enhancing thrombin's action. This suggests that PAR-3's primary function is not as a signal transmitter across the membrane, but rather as a cofactor necessary for PAR-4 activation.

• Smiles:

  C (CNC (CNC ([C@@H] (NC ([C@H] (CC1=CC=CC=C1) NC ([C@H] (CO) N) =O) =O) CC (N) =O) =O) =O) (=O) N2[C@H] (C (N) =O) CCC2

• Molecular Formula:

  C25H36N8O8

• Molecular Weight:

  576.6

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  261521-21-5