SFNGGP-NH2

CAT: 0931-MF-0157799-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0157799-01Size:5 mg
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CAS Number
261521-21-5
Target
Protease-activated Receptor
Related Pathways
GPCR/G Protein
Bioactivity
SFNGGP-NH2 is a biologically active peptide that interacts with Protease-Activated Receptor 3 (PAR-3), a high-affinity thrombin receptor. Human cutaneous mast cells express PAR-3 mRNA, implicating a role in itch mechanotransduction, with both histamine-dependent and independent pathways reported. While PAR-3 alone does not induce itch, it may potentiate itch when co-expressed with PAR-4, enhancing thrombin's action. This suggests that PAR-3's primary function is not as a signal transmitter across the membrane, but rather as a cofactor necessary for PAR-4 activation.
Smiles
C(CNC(CNC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@H](CO)N)=O)=O)CC(N)=O)=O)=O)(=O)N2[C@H](C(N)=O)CCC2
Molecular Formula
C25H36N8O8
Molecular Weight
576.6
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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