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Bid BH3 (80-99)

CAT: 0931-T80224-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T80224-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
505070-05-3
Target
Bcl-2 Family
Related Pathways
Apoptosis
Bioactivity
Bid BH3 (80-99) is a biologically active peptide and a pro-apoptotic member of the 'BH3-only' (BOPS) subset within the BCL-2 protein family, crucial in apoptosis regulation. It interacts with Bcl-2, Bax, and Bak to initiate their activation or inactivation, inducing cell death. Bid translocates from the cytosol to the mitochondrial membrane as part of its mechanism. Pyroglutamyl (pGlu) peptides, which can arise from Glutamine (Q) or Glutamic acid (E) at the N-terminus, have a hydrophobic γ-lactam ring that enhances stability and provides resistance to gastrointestinal proteases. These peptides are recognized variants in peptide analyses, including HPLC purity assessments.
Smiles
[C@@H](CC1=CN=CN1)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)N)=O)CC(O)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CCCNC(=N)N)=O)CC(N)=O)=O)[C@H](CC)C)=O)C)=O)CCCNC(=N)N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)CC(O)=O)=O)CCSC)=O)CO)=O)CC(O)=O)=O)=O)[C@H](C)C)=O)CCC(N)=O)=O)C)=O)CC(C)C)=O
Molecular Formula
C95H161N33O32S
Molecular Weight
2309.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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